[HTML][HTML] Tumor necrosis factor α enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway
LC Gahring, AV Osborne-Hereford… - Journal of biological …, 2008 - ASBMB
A response by key neuronal nicotinic acetylcholine receptors (nAChRs) to sustained
nicotine exposure is up-regulation. Although this unusual receptor characteristic contributes
to processes ranging from aging to addiction, the normal physiologic reason for this
response is unknown. We find that up-regulation of [3 H] epibatidine binding and function in
HEK293 cells stably expressing α4β2-nAChR is significantly enhanced by co-application of
the proinflammatory cytokine, tumor necrosis factor α. The mechanism of tumor necrosis …
nicotine exposure is up-regulation. Although this unusual receptor characteristic contributes
to processes ranging from aging to addiction, the normal physiologic reason for this
response is unknown. We find that up-regulation of [3 H] epibatidine binding and function in
HEK293 cells stably expressing α4β2-nAChR is significantly enhanced by co-application of
the proinflammatory cytokine, tumor necrosis factor α. The mechanism of tumor necrosis …