[HTML][HTML] Integrating mutation variant allele frequency into clinical practice in myeloid malignancies

DA Sallman, E Padron - Hematology/oncology and stem cell therapy, 2016 - Elsevier
DA Sallman, E Padron
Hematology/oncology and stem cell therapy, 2016Elsevier
Hematologic myeloid neoplasms represent a heterogeneous group of disorders with defined
clinical and pathologic characteristics. However, intensive investigation into the genetic
abnormalities of these diseases has not only significantly advanced our understanding, but
also revolutionized our diagnostic and prognostic capabilities. Moreover, more recent
discovery on the impact of clonal burden has highlighted the critical and dynamic role of
clonal evolution over time, which is integrally linked to a patient's clinical trajectory. This …
Abstract
Hematologic myeloid neoplasms represent a heterogeneous group of disorders with defined clinical and pathologic characteristics. However, intensive investigation into the genetic abnormalities of these diseases has not only significantly advanced our understanding, but also revolutionized our diagnostic and prognostic capabilities. Moreover, more recent discovery on the impact of clonal burden has highlighted the critical and dynamic role of clonal evolution over time, which is integrally linked to a patient’s clinical trajectory. This review will highlight the evidence supporting the incorporation of allelic burden of somatic mutations into clinical practice for the diagnosis and prognosis of myeloid neoplasms.
Elsevier