Myeloid-derived suppressor cells (MDSCs) have garnered much attention in recent years as
a potential target for altering the immunosuppressive tumor microenvironment in a variety of
solid tumor types. The ability to accurately assess the immunosuppressive capacity of
MDSCs is fundamental to the development of therapeutic approaches aimed at disabling
these immunosuppressive functions. In this article we provide evidence that the use of
CD3/28 coated microbeads leads to artefactual T-lymphocyte suppression due to …