Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and
approaches have provided exciting insights into these processes, and numerous
investigators have shown that selective PT cell defects lead to significant albuminuria, even
reaching nephrotic range in animal models. Thus, the mechanisms of albumin reabsorption
and transcytosis are undergoing intense study. Working in concert with megalin and cubilin …