What is the glomerular ultrafiltration barrier?
WH Fissell, JH Miner - Journal of the American Society of …, 2018 - journals.lww.com
Since the unique features of the threelayered glomerular capillary wall between the blood
and the urine were first visualized by electron microscopy, the identity of the definitive
components that restrict the filtration of albumin, Igs, and other large plasma constituents has
been controversial. Because proteinuria is the single strongest predictor of progression from
CKD to renal failure, 1 an understanding of what constitutes the ultrafiltration barrier and
how it is maintained is critical. It is evident that all three layers of the glomerular capillary wall …
and the urine were first visualized by electron microscopy, the identity of the definitive
components that restrict the filtration of albumin, Igs, and other large plasma constituents has
been controversial. Because proteinuria is the single strongest predictor of progression from
CKD to renal failure, 1 an understanding of what constitutes the ultrafiltration barrier and
how it is maintained is critical. It is evident that all three layers of the glomerular capillary wall …