[HTML][HTML] Clinicopathologic and prognostic value of serum carbohydrate antigen 19-9 in gastric cancer: a meta-analysis

Y Song, X Huang, P Gao, J Sun, X Chen, Y Yang… - Disease …, 2015 - hindawi.com
Y Song, X Huang, P Gao, J Sun, X Chen, Y Yang, C Zhang, H Liu, H Wang, Z Wang
Disease Markers, 2015hindawi.com
Background. The clinical value of carbohydrate antigen (CA) 19-9 in gastric cancer is
controversial. We evaluated the clinicopathologic and prognostic value of CA 19-9 in gastric
cancer. Methods. A literature search was conducted in PubMed and Embase databases.
Odds ratios (ORs), risk ratios (RR), hazard ratios (HRs), and 95% confidence intervals (CIs)
were used as effect measures. Results. Thirty-eight studies were included. Results showed
that there were significant differences in the incidence of high CA 19-9 levels between …
Background. The clinical value of carbohydrate antigen (CA) 19-9 in gastric cancer is controversial. We evaluated the clinicopathologic and prognostic value of CA 19-9 in gastric cancer. Methods. A literature search was conducted in PubMed and Embase databases. Odds ratios (ORs), risk ratios (RR), hazard ratios (HRs), and 95% confidence intervals (CIs) were used as effect measures. Results. Thirty-eight studies were included. Results showed that there were significant differences in the incidence of high CA 19-9 levels between stages III/IV and I/II groups (OR = 3.36; 95% CI = 2.34–4.84), the pT3/T4 and pT1/T2 groups (OR = 2.40; 95% CI = 1.60–3.59), the lymph node-positive and node-negative groups (OR = 2.91; 95% CI = 2.21–3.84), the metastasis-positive and metastasis-negative groups (OR = 2.76; 95% CI = 1.12–6.82), and vessel invasion-positive and invasion-negative groups (OR = 1.66; 95% CI = 1.11–2.48). Moreover, CA 19-9 was significantly associated with poor overall survival (HR = 1.83; 95% CI = 1.56–2.15), disease-free survival (HR = 1.85; 95% CI = 1.16–2.95), and disease-specific survival (HR = 1.33; 95% CI = 1.10–1.60) in gastric cancer. Conclusions. Our meta-analysis showed that CA 19-9 indicates clinicopathologic characteristics of gastric cancer and is associated with a poor prognosis.
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