Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues
The antimicrobial peptide Liver Expressed Antimicrobial Peptide-2 (LEAP-2) is proposed to
function as part of the vertebrate innate immune system. However, the highly conserved
nature of the LEAP-2 peptide primary structure among vertebrates suggests more
fundamental physiological roles. RT-PCR analyses confirmed expression of LEAP-2 mRNA
variants in human gastro-intestinal (GI) epithelial tissues and THP-1 monocytes. Three
cDNA products indicative of at least three different spliced transcripts were observed …
function as part of the vertebrate innate immune system. However, the highly conserved
nature of the LEAP-2 peptide primary structure among vertebrates suggests more
fundamental physiological roles. RT-PCR analyses confirmed expression of LEAP-2 mRNA
variants in human gastro-intestinal (GI) epithelial tissues and THP-1 monocytes. Three
cDNA products indicative of at least three different spliced transcripts were observed …