[HTML][HTML] Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids
RL Li, DP Sherbet, BL Elsbernd, JL Goldstein… - Journal of Biological …, 2012 - ASBMB
When mice are subjected to 7-day calorie restriction (40% of normal food intake), body fat
disappears, but blood glucose is maintained as long as the animals produce ghrelin, an
octanoylated peptide that stimulates growth hormone secretion. Mice can be rendered
ghrelin-deficient by knock-out of the gene encoding either ghrelin O-acyltransferase, which
attaches the required octanoate, or ghrelin itself. Calorie-restricted, fat-depleted ghrelin O-
acyltransferase or ghrelin knock-out mice fail to show the normal increase in growth …
disappears, but blood glucose is maintained as long as the animals produce ghrelin, an
octanoylated peptide that stimulates growth hormone secretion. Mice can be rendered
ghrelin-deficient by knock-out of the gene encoding either ghrelin O-acyltransferase, which
attaches the required octanoate, or ghrelin itself. Calorie-restricted, fat-depleted ghrelin O-
acyltransferase or ghrelin knock-out mice fail to show the normal increase in growth …