[HTML][HTML] Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress
MC Gold, T Eid, S Smyk-Pearson, Y Eberling… - Mucosal …, 2013 - Elsevier
Human mucosal-associated invariant T (MAIT) cells express the semi-invariant T-cell
receptor (TCR) Vα7. 2 and are restricted by the major histocompatibility complex-Ib molecule
MR1. While MAIT cells share similarities with other innate T cells, the extent to which MAIT
cells are innate and their capacity to adapt is unknown. We evaluated the function of Vα7. 2+
T cells from the thymus, cord blood, and peripheral blood. Although antigen-inexperienced
MAIT cells displayed a naïve phenotype, these had intrinsic effector capacity in response to …
receptor (TCR) Vα7. 2 and are restricted by the major histocompatibility complex-Ib molecule
MR1. While MAIT cells share similarities with other innate T cells, the extent to which MAIT
cells are innate and their capacity to adapt is unknown. We evaluated the function of Vα7. 2+
T cells from the thymus, cord blood, and peripheral blood. Although antigen-inexperienced
MAIT cells displayed a naïve phenotype, these had intrinsic effector capacity in response to …