[HTML][HTML] Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease
M Friedrich, J Diegelmann, J Schauber… - Mucosal …, 2015 - Elsevier
Abstract Interleukin (IL)-17C is a novel member of the IL-17 cytokine family. Its function in
human inflammatory bowel disease (IBD) remains elusive as its role in colonic inflammation
is entirely derived from murine models. We aimed to analyze the role of IL-17C in human
IBD, focusing on T helper type 17 (Th17) cell-and intestinal epithelial cell (IEC)-dependent
mechanisms. IL-17C mRNA (P= 0.005), serum levels (P= 0.008), and colonic staining
intensity (P= 0.004) is increased in active IBD. Serum IL-17C levels are modified by IL23R …
human inflammatory bowel disease (IBD) remains elusive as its role in colonic inflammation
is entirely derived from murine models. We aimed to analyze the role of IL-17C in human
IBD, focusing on T helper type 17 (Th17) cell-and intestinal epithelial cell (IEC)-dependent
mechanisms. IL-17C mRNA (P= 0.005), serum levels (P= 0.008), and colonic staining
intensity (P= 0.004) is increased in active IBD. Serum IL-17C levels are modified by IL23R …