TMEM25 is a candidate biomarker methylated and down-regulated in colorectal cancer
S Hrašovec, N Hauptman, D Glavač, F Jelenc… - Disease …, 2013 - content.iospress.com
S Hrašovec, N Hauptman, D Glavač, F Jelenc, M Ravnik-Glavač
Disease markers, 2013•content.iospress.comThe identification of novel genes involved in colorectal cancerogenesis is of high clinical
relevance for early diagnosis, applying new therapeutic strategies and monitoring disease
recurrence, in order to reduce disease incidence and mortality. Gene silencing through CpG
island hypermethylation is a major epigenetic mechanism involved in cancer development.
In our study, we aimed to identify and validate novel genes with a tumour specific DNA
methylation profile in colorectal cancer.
relevance for early diagnosis, applying new therapeutic strategies and monitoring disease
recurrence, in order to reduce disease incidence and mortality. Gene silencing through CpG
island hypermethylation is a major epigenetic mechanism involved in cancer development.
In our study, we aimed to identify and validate novel genes with a tumour specific DNA
methylation profile in colorectal cancer.
Abstract
The identification of novel genes involved in colorectal cancerogenesis is of high clinical relevance for early diagnosis, applying new therapeutic strategies and monitoring disease recurrence, in order to reduce disease incidence and mortality. Gene silencing through CpG island hypermethylation is a major epigenetic mechanism involved in cancer development. In our study, we aimed to identify and validate novel genes with a tumour specific DNA methylation profile in colorectal cancer.
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