Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival
Arginine vasopressin (AVP), a peptide secreted from the posterior pituitary, is chiefly
regarded as a hormone involved in the regulation of body fluid balance and osmolality.
However, recent evidence has revealed that posterior pituitary hormones can exert
important actions on endocrine pancreatic function. In the present study, the presence of
AVP receptors, namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2) was demonstrated in
murine islets as well as rodent BRIN BD11 and human 1.1 B4 beta-cells. Further to this, AVP …
regarded as a hormone involved in the regulation of body fluid balance and osmolality.
However, recent evidence has revealed that posterior pituitary hormones can exert
important actions on endocrine pancreatic function. In the present study, the presence of
AVP receptors, namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2) was demonstrated in
murine islets as well as rodent BRIN BD11 and human 1.1 B4 beta-cells. Further to this, AVP …