Retinal vasculature development in health and disease

S Selvam, T Kumar, M Fruttiger - Progress in retinal and eye research, 2018 - Elsevier
S Selvam, T Kumar, M Fruttiger
Progress in retinal and eye research, 2018Elsevier
Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with
external influences such as the supply of oxygen and nutrients. The developing mouse
retinal vasculature is a useful model system to study these interactions because it is
experimentally accessible for intra ocular injections and genetic manipulations, can be
easily imaged and develops in a similar fashion to that of humans. Research using this …
Abstract
Development of the retinal vasculature is based on highly coordinated signalling between different cell types of the retina, integrating internal metabolic requirements with external influences such as the supply of oxygen and nutrients. The developing mouse retinal vasculature is a useful model system to study these interactions because it is experimentally accessible for intra ocular injections and genetic manipulations, can be easily imaged and develops in a similar fashion to that of humans. Research using this model has provided insights about general principles of angiogenesis as well as pathologies that affect the developing retinal vasculature. In this review, we discuss recent advances in our understanding of the molecular and cellular mechanisms that govern the interactions between neurons, glial and vascular cells in the developing retina. This includes a review of mechanisms that shape the retinal vasculature, such as sprouting angiogenesis, vascular network remodelling and vessel maturation. We also explore how the disruption of these processes in mice can lead to pathology - such as oxygen induced retinopathy - and how this translates to human retinopathy of prematurity.
Elsevier