Control of early viral and bacterial distribution and disease by natural antibodies
AF Ochsenbein, T Fehr, C Lutz, M Suter, F Brombacher… - Science, 1999 - science.org
AF Ochsenbein, T Fehr, C Lutz, M Suter, F Brombacher, H Hengartner, RM Zinkernagel
Science, 1999•science.orgNatural antibodies are often dismissed from immunological analysis as “background,” but
they may play an important role in conferring immunity against infections. In antibody-free
mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in
peripheral organs, including the kidney and brain, were 10 to 100 times greater than in
antibody-competent mice (and enhanced their susceptibility to some infections), and titers in
secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice …
they may play an important role in conferring immunity against infections. In antibody-free
mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in
peripheral organs, including the kidney and brain, were 10 to 100 times greater than in
antibody-competent mice (and enhanced their susceptibility to some infections), and titers in
secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice …
Natural antibodies are often dismissed from immunological analysis as “background,” but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.
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