Inhibition of Toll-like receptor 9 attenuates sepsis-induced mortality through suppressing excessive inflammatory response
D Hu, X Yang, Y Xiang, H Li, H Yan, J Zhou… - Cellular …, 2015 - Elsevier
Sepsis, a major clinical problem with high morbidity and mortality, is caused by
overwhelming systemic host-inflammatory response. Toll-like receptors (TLRs) play a
fundamental role in induction of hyperinflammation and tissue damage in sepsis. In this
study, we demonstrate a protective role of TLR9 inhibition against the dysregulated
inflammatory response and tissue injury in sepsis. TLR9 deficiency decreased the mortality
of mice following cecal ligation and puncture (CLP)-induced sepsis. TLR9 knockout mice …
overwhelming systemic host-inflammatory response. Toll-like receptors (TLRs) play a
fundamental role in induction of hyperinflammation and tissue damage in sepsis. In this
study, we demonstrate a protective role of TLR9 inhibition against the dysregulated
inflammatory response and tissue injury in sepsis. TLR9 deficiency decreased the mortality
of mice following cecal ligation and puncture (CLP)-induced sepsis. TLR9 knockout mice …