[HTML][HTML] Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids
E Vladykovskaya, E Ozhegov, JD Hoetker, Z Xie… - Journal of lipid …, 2011 - ASBMB
The generation of oxidized phospholipids in lipoproteins has been linked to vascular
inflammation in atherosclerotic lesions. Products of phospholipid oxidation increase
endothelial activation; however, their effects on macrophages are poorly understood, and it
is unclear whether these effects are regulated by the biochemical pathways that metabolize
oxidized phospholipids. We found that incubation of 1-palmitoyl-2-(5′-oxo-valeroyl)-sn-
glycero-3-phosphocholine (POVPC) with THP-1-derived macrophages upregulated the …
inflammation in atherosclerotic lesions. Products of phospholipid oxidation increase
endothelial activation; however, their effects on macrophages are poorly understood, and it
is unclear whether these effects are regulated by the biochemical pathways that metabolize
oxidized phospholipids. We found that incubation of 1-palmitoyl-2-(5′-oxo-valeroyl)-sn-
glycero-3-phosphocholine (POVPC) with THP-1-derived macrophages upregulated the …
