Macrophage receptors and immune recognition

PR Taylor, L Martinez-Pomares, M Stacey… - Annu. Rev …, 2005 - annualreviews.org
PR Taylor, L Martinez-Pomares, M Stacey, HH Lin, GD Brown, S Gordon
Annu. Rev. Immunol., 2005annualreviews.org
▪ Abstract Macrophages express a broad range of plasma membrane receptors that mediate
their interactions with natural and altered-self components of the host as well as a range of
microorganisms. Recognition is followed by surface changes, uptake, signaling, and altered
gene expression, contributing to homeostasis, host defense, innate effector mechanisms,
and the induction of acquired immunity. This review covers recent studies of selected
families of structurally defined molecules, studies that have improved understanding of …
▪ Abstract 
Macrophages express a broad range of plasma membrane receptors that mediate their interactions with natural and altered-self components of the host as well as a range of microorganisms. Recognition is followed by surface changes, uptake, signaling, and altered gene expression, contributing to homeostasis, host defense, innate effector mechanisms, and the induction of acquired immunity. This review covers recent studies of selected families of structurally defined molecules, studies that have improved understanding of ligand discrimination in the absence of opsonins and differential responses by macrophages and related myeloid cells.
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