[HTML][HTML] TDP-43 overexpression impairs presynaptic integrity
L Heyburn, CEH Moussa - Neural Regeneration Research, 2016 - journals.lww.com
The pathological mechanisms associated with the trans-activating response DNA/RNA
binding protein (TDP)-43 remain largely enigmatic. Accumulation, insolubility and post-
translational modification of nuclear and cytoplasmic TDP-43 are evident in many
neurodegenerative diseases. TDP-43 constitutes one of the major molecular pathologies
associated with RNA metabolism. Human neuronal TDP-43 overexpression suppresses
mRNA translation and expression of housekeeping synaptic proteins, which facilitate the …
binding protein (TDP)-43 remain largely enigmatic. Accumulation, insolubility and post-
translational modification of nuclear and cytoplasmic TDP-43 are evident in many
neurodegenerative diseases. TDP-43 constitutes one of the major molecular pathologies
associated with RNA metabolism. Human neuronal TDP-43 overexpression suppresses
mRNA translation and expression of housekeeping synaptic proteins, which facilitate the …