[HTML][HTML] Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses
C Germain, A Meier, T Jensen, P Knapnougel… - Journal of Biological …, 2011 - ASBMB
CD161 is a C-type lectin-like receptor expressed on human natural killer (NK) cells and
subsets of T cells. CD161 has been described as an inhibitory receptor that regulates NK
cell-mediated cytotoxicity and IFN-γ production. Its role on T cells has remained unclear.
Studies have shown that triggering of CD161 enhances NK T cell proliferation and T cell-IFN-
γ production while inhibiting TNF-α production by CD8+ T cells. Lectin-like transcript 1
(LLT1), the ligand of CD161, was found to be expressed on Toll-like receptor (TLR) …
subsets of T cells. CD161 has been described as an inhibitory receptor that regulates NK
cell-mediated cytotoxicity and IFN-γ production. Its role on T cells has remained unclear.
Studies have shown that triggering of CD161 enhances NK T cell proliferation and T cell-IFN-
γ production while inhibiting TNF-α production by CD8+ T cells. Lectin-like transcript 1
(LLT1), the ligand of CD161, was found to be expressed on Toll-like receptor (TLR) …