Targeting the intratumoral dendritic cells by the oncolytic adenoviral vaccine expressing RANTES elicits potent antitumor immunity
N Lapteva, M Aldrich, D Weksberg… - Journal of …, 2009 - journals.lww.com
Dendritic cells (DCs) are professional antigen (Ag)-presenting cells capable of inducing
immune responses to tumor Ags and, therefore, play a central role in the induction of
antitumor immunity. There is a large amount of evidence, however, about paucity of tumor-
associated DCs and that DCs' immunogenic functions are suppressed in a tumor
environment. Here we describe a potent in situ vaccine targeting tumoral DCs in vivo. This
vaccine comprised of an oncolytic adenovirus expressing RANTES (regulated upon …
immune responses to tumor Ags and, therefore, play a central role in the induction of
antitumor immunity. There is a large amount of evidence, however, about paucity of tumor-
associated DCs and that DCs' immunogenic functions are suppressed in a tumor
environment. Here we describe a potent in situ vaccine targeting tumoral DCs in vivo. This
vaccine comprised of an oncolytic adenovirus expressing RANTES (regulated upon …