Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization

J Maamary, TT Wang, GS Tan… - Proceedings of the …, 2017 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2017National Acad Sciences
The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine
that elicits broad protection against different virus strains. Studies in preclinical models of
influenza virus infections have shown that antibodies alone are sufficient to provide broad
protection against divergent virus strains in vivo. Here, we address the challenge of
identifying an immunogen that can elicit potent, broadly protective, antiinfluenza antibodies
by demonstrating that immune complexes composed of sialylated antihemagglutinin …
The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains. Studies in preclinical models of influenza virus infections have shown that antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo. Here, we address the challenge of identifying an immunogen that can elicit potent, broadly protective, antiinfluenza antibodies by demonstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal inactivated flu vaccine (TIV) can elicit broadly protective antihemagglutinin antibodies. Further, we found that an Fc-modified, bispecific monoclonal antibody against conserved epitopes of the hemagglutinin can be combined with TIV to elicit broad protection, thus setting the stage for a universal influenza virus vaccine.
National Acad Sciences