C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans
CP Alvarez, F Lasala, J Carrillo, O Muñiz… - Journal of …, 2002 - Am Soc Microbiol
Journal of virology, 2002•Am Soc Microbiol
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic
fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN
act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of
dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped
lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role
for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN
act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of
dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped
lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role
for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
Abstract
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
American Society for Microbiology