Signaling by antibodies: recent progress

S Bournazos, TT Wang, R Dahan… - Annual review of …, 2017 - annualreviews.org
Annual review of immunology, 2017annualreviews.org
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity
through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed,
balanced IgG signaling through type I and type II Fc receptors is required for the control of
proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we
discuss the mechanisms that govern IgG–Fc receptor interactions, highlighting the diversity
of Fc receptor–mediated effector functions that regulate immunity and inflammation as well …
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG–Fc receptor interactions, highlighting the diversity of Fc receptor–mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.
Annual Reviews