Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

AM Kazi, MM Cortese, Y Yu, B Lopman… - The Journal of …, 2017 - academic.oup.com
AM Kazi, MM Cortese, Y Yu, B Lopman, AL Morrow, JA Fleming, MM McNeal, AD Steele
The Journal of infectious diseases, 2017academic.oup.com
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for
rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P [8]
rotavirus vaccine trial who were seronegative at baseline, anti–rotavirus immunoglobulin A
seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA
phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not
express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among …
Abstract
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti–rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non–blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
Oxford University Press