[HTML][HTML] In vivo regulation of murine granzyme B gene transcription in activated primary T cells
CK Babichuk, BL Duggan, RC Bleackley - Journal of Biological Chemistry, 1996 - ASBMB
A murine granzyme B promoter fragment that extends 243 base pairs upstream of the
transcription start site confers high levels of luciferase reporter gene activity in transient
transfection assays into T cells and mouse L cell fibroblasts. This promoter fragment
contains canonical binding sites for the transcription factors AP-1, core binding factor (CBF),
Ikaros, and the cyclic AMP responsive element binding protein (CREB). Oligonucleotides
containing the granzyme B AP-1 or CBF elements form specific complexes with proteins …
transcription start site confers high levels of luciferase reporter gene activity in transient
transfection assays into T cells and mouse L cell fibroblasts. This promoter fragment
contains canonical binding sites for the transcription factors AP-1, core binding factor (CBF),
Ikaros, and the cyclic AMP responsive element binding protein (CREB). Oligonucleotides
containing the granzyme B AP-1 or CBF elements form specific complexes with proteins …