Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury

GR Kinsey, R Sharma, L Huang, L Li… - Journal of the …, 2009 - journals.lww.com
Both innate and adaptive mechanisms participate in the pathogenesis of kidney ischemia-
reperfusion injury (IRI), but the role of regulatory immune mechanisms is unknown. We
hypothesized that the anti-inflammatory effects of CD4+ CD25+ FoxP3+ regulatory T cells
(Tregs) protect against renal IRI. Partial depletion of Tregs with an anti-CD25 mAb
potentiated kidney damage induced by IRI. Reducing the number of Tregs resulted in more
neutrophils, macrophages, and innate cytokine transcription in the kidney after IRI but did …