ERK1, 2, and 5 expression and activation in dopaminergic brain regions during postnatal development

MS Parmar, JD Jaumotte, MJ Zigmond… - International Journal of …, 2015 - Elsevier
Degeneration and dysfunctioning of dopaminergic neurons in the midbrain have been
associated with serious neurodegenerative and neuropsychiatric disorders. Elucidating the
underlying neurobiology of these neurons during early postnatal development may provide
important information regarding the etiology of these disorders. Cellular signaling pathways
have been shown to regulate postnatal neuronal development. Among several signaling
pathways, extracellular-regulated mitogen kinases (ERK) 1, 2, and 5 have been shown to be …