Reactive oxygen species (ROS), often also referred to as free radicals, play an important
role in aging. It is widely assumed that mitochondria are the predominant source of ROS
relevant for the aging process. In this hypothesis article, we suggest that the role of ROS
generated by NOX family NADPH oxidases has been largely overlooked in aging theories.
NOX NADPH oxidases form a seven member gene family and are high level ROS-
generating enzymes. As opposed to mitochondria, which generate ROS as a byproduct of …