Cardiac mitochondrial phospholipid acyl chains regulate respiratory enzymatic activity. In
several diseases, the rodent cardiac phospholipidome is extensively rearranged; however,
whether specific acyl chains impair respiratory enzyme function is unknown. One unique
remodeling event in the myocardium of obese and diabetic rodents is an increase in
docosahexaenoic acid (DHA) levels. Here, we first confirmed that cardiac DHA levels are
elevated in diabetic humans relative to controls. We then used dietary supplementation of a …