Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells.
K Iwami, T Moriyama - The International journal of biochemistry, 1993 - europepmc.org
K Iwami, T Moriyama
The International journal of biochemistry, 1993•europepmc.org1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell
line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not
affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate
decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC)
formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone
marrow cells.
line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not
affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate
decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC)
formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone
marrow cells.
1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.
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