[HTML][HTML] A cut above the rest: targeted genome editing technologies in human pluripotent stem cells

M Li, K Suzuki, NY Kim, GH Liu, JCI Belmonte - Journal of Biological …, 2014 - ASBMB
Human pluripotent stem cells (hPSCs) offer unprecedented opportunities to study cellular
differentiation and model human diseases. The ability to precisely modify any genomic
sequence holds the key to realizing the full potential of hPSCs. Thanks to the rapid
development of novel genome editing technologies driven by the enormous interest in the
hPSC field, genome editing in hPSCs has evolved from being a daunting task a few years
ago to a routine procedure in most laboratories. Here, we provide an overview of the …