[HTML][HTML] Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: implication of natural antisense HIF …
T Uchida, F Rossignol, MA Matthay, R Mounier… - Journal of Biological …, 2004 - ASBMB
Transcriptional adaptations to hypoxia are mediated by hypoxia-inducible factor (HIF)-1, a
heterodimer of HIF-α and aryl hydrocarbon receptor nuclear translocator subunits. The HIF-
1α and HIF-2α subunits both undergo rapid hypoxia-induced protein stabilization and bind
identical target DNA sequences. When coexpressed in similar cell types, discriminating
control mechanisms may exist for their regulation, explaining why HIF-1α and HIF-2α do not
substitute during embryogenesis. We report that, in a human lung epithelial cell line (A549) …
heterodimer of HIF-α and aryl hydrocarbon receptor nuclear translocator subunits. The HIF-
1α and HIF-2α subunits both undergo rapid hypoxia-induced protein stabilization and bind
identical target DNA sequences. When coexpressed in similar cell types, discriminating
control mechanisms may exist for their regulation, explaining why HIF-1α and HIF-2α do not
substitute during embryogenesis. We report that, in a human lung epithelial cell line (A549) …