Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
T Hirota, A Takahashi, M Kubo, T Tsunoda, K Tomita… - Nature …, 2012 - nature.com
T Hirota, A Takahashi, M Kubo, T Tsunoda, K Tomita, M Sakashita, T Yamada, S Fujieda…
Nature genetics, 2012•nature.comAtopic dermatitis is a common inflammatory skin disease caused by interaction of genetic
and environmental factors. On the basis of data from a genome-wide association study
(GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis
and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci:
IL1RL1-IL18R1-IL18RAP (P combined= 8.36× 10− 18), the major histocompatibility complex
(MHC) region (P= 8.38× 10− 20), OR10A3-NLRP10 (P= 1.54× 10− 22), GLB1 (P= 2.77× 10 …
and environmental factors. On the basis of data from a genome-wide association study
(GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis
and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci:
IL1RL1-IL18R1-IL18RAP (P combined= 8.36× 10− 18), the major histocompatibility complex
(MHC) region (P= 8.38× 10− 20), OR10A3-NLRP10 (P= 1.54× 10− 22), GLB1 (P= 2.77× 10 …
Abstract
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (Pcombined = 8.36 × 10−18), the major histocompatibility complex (MHC) region (P = 8.38 × 10−20), OR10A3-NLRP10 (P = 1.54 × 10−22), GLB1 (P = 2.77 × 10−16), CCDC80 (P = 1.56 × 10−19), CARD11 (P = 7.83 × 10−9), ZNF365 (P = 5.85 × 10−20) and CYP24A1-PFDN4 (P = 1.65 × 10−8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
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