Staphylococcus aureus inhibits terminal differentiation of normal human keratinocytes by stimulating interleukin-6 secretion
ED Son, HJ Kim, T Park, K Shin, IH Bae, KM Lim… - Journal of …, 2014 - Elsevier
Background Staphylococcus aureus (S. aureus) is found on the skin of approximately 90%
of patients with atopic dermatitis and approximately 20% of apparently healthy subjects. S.
aureus induces keratinocytes and immune cells to secrete immunoregulatory factors that
cause epidermal barrier dysfunction in atopic skin. Objective This study examined factors
that cause epidermal permeability barrier dysfunction in skin colonized by S. aureus.
Methods We examined the effect of S. aureus on keratinocyte differentiation in the stratum …
of patients with atopic dermatitis and approximately 20% of apparently healthy subjects. S.
aureus induces keratinocytes and immune cells to secrete immunoregulatory factors that
cause epidermal barrier dysfunction in atopic skin. Objective This study examined factors
that cause epidermal permeability barrier dysfunction in skin colonized by S. aureus.
Methods We examined the effect of S. aureus on keratinocyte differentiation in the stratum …