[HTML][HTML] Cardiovascular disease protection in long-duration type 1 diabetes and sex differences

ZH He, AD Stephanie, LJ Tinsley, S Fitzgerald… - Diabetes …, 2015 - ncbi.nlm.nih.gov
ZH He, AD Stephanie, LJ Tinsley, S Fitzgerald, SM Hastings, M Khamaisi, JK Sun, SJ Turek…
Diabetes Care, 2015ncbi.nlm.nih.gov
Two recent articles describe higher morbidity and mortality from cardiovascular disease
(CVD) at younger ages for women with type 1 diabetes compared with men in cohorts with
average duration of approximately 30 years (1, 2). Women in the Joslin 50-Year Medalist
Study (total n 5 680) have a significantly lower CVD prevalence than men (women 35.3% vs.
men 51.6%, P, 0.001), suggesting a protective factor. The objective of this analysis was to
investigate protective factors associated with CVD and sex-associated differences in rates in …
Two recent articles describe higher morbidity and mortality from cardiovascular disease (CVD) at younger ages for women with type 1 diabetes compared with men in cohorts with average duration of approximately 30 years (1, 2). Women in the Joslin 50-Year Medalist Study (total n 5 680) have a significantly lower CVD prevalence than men (women 35.3% vs. men 51.6%, P, 0.001), suggesting a protective factor. The objective of this analysis was to investigate protective factors associated with CVD and sex-associated differences in rates in those with long-term type 1 diabetes.
The Joslin 50-Year Medalist Study is a cross-sectional study of individuals with 50 or more years of type 1 diabetes (n= 651). To be awarded the Joslin 50-Year Medal, individuals provide an original medical record from time of diagnosis, or three other forms of documentation of insulin dependence since the time of diagnosis 50 or more years before the date of application for the medal. Participants underwent a clinical exam, biospecimen collection and completed a medical history questionnaire that included assessment of physical activity. CVD status was based on self-reported history of coronary artery disease, angina, heart attack, prior cardiac or leg angioplasty, or bypass graft surgery of participants (3); several studies have
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