Systemic safety of prolonged monthly anti–vascular endothelial growth factor therapy for diabetic macular edema: a systematic review and meta-analysis

RL Avery, GM Gordon - JAMA ophthalmology, 2016 - jamanetwork.com
Importance Anti–vascular endothelial growth factor (VEGF) therapy is commonly used to
treat numerous retinal conditions and appears safe, yet controversy remains regarding
systemic safety. Objective To evaluate the systemic safety of intravitreous anti-VEGF
injections in high-risk patients with diabetic macular edema (DME) and to investigate
separately the subgroup of these patients with the highest level of exposure to anti-VEGF
monthly treatment for 2 years. Data Sources A search of MEDLINE, Cochrane Central …