[HTML][HTML] Tumor necrosis factor α inhibits glutamate uptake by primary human astrocytes: implications for pathogenesis of HIV-1 dementia

SM Fine, RA Angel, SW Perry, LG Epstein… - Journal of Biological …, 1996 - ASBMB
Human immunodeficiency virus (HIV) infection is commonly associated with neurological
disease that occurs in the apparent absence of extensive infection of brain cells by HIV,
suggesting that indirect mechanisms account for neuropathogenesis in the CNS, perhaps
including changes in the normal neuroprotective functions of astrocytes. To test this
hypothesis, we examined the effect of the pro-inflammatory cytokine, tumor necrosis factor α
(TNFα), produced by HIV-1-infected macrophages and microglia, on glutamate transport by …