A functional screen for Krüppel-like factors that regulate the human γ-globin gene through the CACCC promoter element
P Zhang, P Basu, LC Redmond, PE Morris… - Blood Cells, Molecules …, 2005 - Elsevier
Krüppel-like factors (KLFs) have been systematically screened as potential candidates to
regulate human γ-globin gene expression through its CACCC element. Initially, 21 human
proteins that have close sequence similarity to EKLF/KLF1, a known regulator of the human
β-globin gene, were identified. The phylogenetic relationship of these 22 KLF/Sp1 proteins
was determined. KLF2/LKLF, KLF3/BKLF, KLF4/GKLF, KLF5/IKLF, KLF8/BKLF3,
KLF11/FKLF, KLF12/AP-2rep and KLF13/FKLF2 were chosen for functional screening. Semi …
regulate human γ-globin gene expression through its CACCC element. Initially, 21 human
proteins that have close sequence similarity to EKLF/KLF1, a known regulator of the human
β-globin gene, were identified. The phylogenetic relationship of these 22 KLF/Sp1 proteins
was determined. KLF2/LKLF, KLF3/BKLF, KLF4/GKLF, KLF5/IKLF, KLF8/BKLF3,
KLF11/FKLF, KLF12/AP-2rep and KLF13/FKLF2 were chosen for functional screening. Semi …