Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice
M Peyrou, L Bourgoin, AL Poher, J Altirriba… - Journal of …, 2015 - Elsevier
Background & Aims PTEN is a dual lipid/protein phosphatase, downregulated in steatotic
livers with obesity or HCV infection. Liver-specific PTEN knockout (LPTEN KO) mice develop
steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly
also enhanced glucose tolerance. This study aimed at understanding the mechanisms by
which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver
diseases. Methods Control and LPTEN KO mice underwent glucose/pyruvate tolerance tests …
livers with obesity or HCV infection. Liver-specific PTEN knockout (LPTEN KO) mice develop
steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly
also enhanced glucose tolerance. This study aimed at understanding the mechanisms by
which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver
diseases. Methods Control and LPTEN KO mice underwent glucose/pyruvate tolerance tests …