[HTML][HTML] Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/mechanistic target of rapamycin (mTOR) by the protein acetylase, GCN5

D Lee, AL Goldberg - Journal of Biological Chemistry, 2015 - ASBMB
NF-κB is best known for its pro-inflammatory and anti-apoptotic actions, but in skeletal
muscle, NF-κB activation is important for atrophy upon denervation or cancer. Here, we
show that also upon fasting, NF-κB becomes activated in muscle and is critical for the
subsequent atrophy. Following food deprivation, the expression and acetylation of the p65 of
NF-κB on lysine 310 increase markedly in muscles. NF-κB inhibition in mouse muscles by
overexpression of the IκBα superrepressor (IκBα-SR) or of p65 mutated at Lys-310 …