Aging in adipocytes: potential impact of inherent, depot-specific mechanisms
MJ Cartwright, T Tchkonia, JL Kirkland - Experimental gerontology, 2007 - Elsevier
Fat mass and tissue distribution change dramatically throughout life. Fat depot sizes reach a
peak by middle or early old age, followed by a substantial decline, together with fat tissue
dysfunction and redistribution in advanced old age. These changes are associated with
health complications, including type 2 diabetes, atherosclerosis, dyslipidemia, thermal
dysregulation, and skin ulcers, particularly in advanced old age. Fat tissue growth occurs
through increases in size and number of fat cells. Fat cells turn over throughout the lifespan …
peak by middle or early old age, followed by a substantial decline, together with fat tissue
dysfunction and redistribution in advanced old age. These changes are associated with
health complications, including type 2 diabetes, atherosclerosis, dyslipidemia, thermal
dysregulation, and skin ulcers, particularly in advanced old age. Fat tissue growth occurs
through increases in size and number of fat cells. Fat cells turn over throughout the lifespan …