Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients …
C Zeng, S Vanoni, D Wu, JM Caldwell… - Journal of Allergy and …, 2018 - Elsevier
Background Eosinophilic esophagitis (EoE) is characterized by histopathologic
modifications of esophageal tissue, including eosinophil-rich inflammation, basal zone
hyperplasia, and dilated intercellular spaces (DIS). The underlying molecular processes that
drive the histopathologic features of EoE remain largely unexplored. Objective We sought to
investigate the involvement of solute carrier family 9, subfamily A, member 3 (SLC9A3) in
esophageal epithelial intracellular pH (pH i) and DIS formation and the histopathologic …
modifications of esophageal tissue, including eosinophil-rich inflammation, basal zone
hyperplasia, and dilated intercellular spaces (DIS). The underlying molecular processes that
drive the histopathologic features of EoE remain largely unexplored. Objective We sought to
investigate the involvement of solute carrier family 9, subfamily A, member 3 (SLC9A3) in
esophageal epithelial intracellular pH (pH i) and DIS formation and the histopathologic …