Regulation of mitochondrial dynamics by dynamin-related protein-1 in acute cardiorenal syndrome
M Sumida, K Doi, E Ogasawara… - Journal of the …, 2015 - journals.lww.com
Experimental evidence has clarified distant organ dysfunctions induced by AKI. Crosstalk
between the kidney and heart, which has been recognized recently as cardiorenal
syndrome, appears to have an important role in clinical settings, but the mechanisms by
which AKI causes cardiac injury remain poorly understood. Both the kidney and heart are
highly energy-demanding organs that are rich in mitochondria. Therefore, we investigated
the role of mitochondrial dynamics in kidney–heart organ crosstalk. Renal ischemia …
between the kidney and heart, which has been recognized recently as cardiorenal
syndrome, appears to have an important role in clinical settings, but the mechanisms by
which AKI causes cardiac injury remain poorly understood. Both the kidney and heart are
highly energy-demanding organs that are rich in mitochondria. Therefore, we investigated
the role of mitochondrial dynamics in kidney–heart organ crosstalk. Renal ischemia …