Myeloma kidney is the major cause of severe irreversible renal failure in patients with
multiple myeloma. This tubulointerstitial injury is a direct consequence of high
concentrations of circulating monoclonal free light chains (FLCs) produced by a clonal
expansion of plasma cells. Early reduction of serum FLCs associates with renal recovery,
but the target threshold of reduction to facilitate renal recovery is unknown. To determine the
relationship between the achieved FLC reduction and renal recovery, we identified 39 …