Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25+ cells
JS Peraino, H Zhang, PV Rajasekera, M Wei… - Journal of …, 2014 - Elsevier
Regulatory T cells (Treg) constitute a major inhibitory cell population which suppresses
immune responses. Thus, Treg have proven to be key players in the induction of
transplantation tolerance, protection from autoimmune disease and prevention of the
development of effective anti-tumor immune reactions. Treg express high levels of the high
affinity interleukin-2 receptor (IL-2R) consisting of IL-2Rα (CD25) together with IL-2Rβ
(CD122) and the common γ-chain (CD132). An effective reagent capable of depleting Treg …
immune responses. Thus, Treg have proven to be key players in the induction of
transplantation tolerance, protection from autoimmune disease and prevention of the
development of effective anti-tumor immune reactions. Treg express high levels of the high
affinity interleukin-2 receptor (IL-2R) consisting of IL-2Rα (CD25) together with IL-2Rβ
(CD122) and the common γ-chain (CD132). An effective reagent capable of depleting Treg …