[HTML][HTML] Platelets contribute to the initiation of colitis‐associated cancer by promoting immunosuppression
L Servais, O Wéra, JD Epoh, C Delierneux… - Journal of Thrombosis …, 2018 - Elsevier
Essentials• Inflammation plays a key role in the development of colorectal cancer.•
Understanding mechanisms of cancer initiation might reveal new anticancer preventive
strategy.• Hyperactive platelets promote tumor formation by fostering immune evasion of
cancer.• Platelet inhibition by clopidogrel prevents carcinogenesis by restoring antitumor
immunity. Summary: Background Clinical and experimental evidence support a role for
inflammation in the development of colorectal cancer, although the mechanisms are not fully …
Understanding mechanisms of cancer initiation might reveal new anticancer preventive
strategy.• Hyperactive platelets promote tumor formation by fostering immune evasion of
cancer.• Platelet inhibition by clopidogrel prevents carcinogenesis by restoring antitumor
immunity. Summary: Background Clinical and experimental evidence support a role for
inflammation in the development of colorectal cancer, although the mechanisms are not fully …