[HTML][HTML] Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype
AJ Freemerman, AR Johnson, GN Sacks… - Journal of Biological …, 2014 - ASBMB
Glucose is a critical component in the proinflammatory response of macrophages (MΦs).
However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating
subsequent glucose metabolism in the inflammatory response are not well understood.
Because MΦs contribute to obesity-induced inflammation, it is important to understand how
substrate metabolism may alter inflammatory function. We report that GLUT1 (SLC2A1) is
the primary rate-limiting glucose transporter on proinflammatory-polarized MΦs …
However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating
subsequent glucose metabolism in the inflammatory response are not well understood.
Because MΦs contribute to obesity-induced inflammation, it is important to understand how
substrate metabolism may alter inflammatory function. We report that GLUT1 (SLC2A1) is
the primary rate-limiting glucose transporter on proinflammatory-polarized MΦs …