NK cell apoptosis in coronary artery disease: relation to oxidative stress
W Li, C Lidebjer, XM Yuan, A Szymanowski… - Atherosclerosis, 2008 - Elsevier
OBJECTIVE: Natural killer (NK) cells, key elements in initiation and modulation of immune
responses, were recently found to be reduced in coronary artery disease (CAD). To clarify
mechanisms behind this reduction, we here investigated NK cell apoptosis in CAD patients.
Since oxidative stress has been linked to NK cell apoptosis, we related the findings to
oxidative stress in vivo and evaluated the ex vivo susceptibility of NK cells to oxidized lipids.
METHODS AND RESULTS: The number of apoptotic NK cells in peripheral blood was …
responses, were recently found to be reduced in coronary artery disease (CAD). To clarify
mechanisms behind this reduction, we here investigated NK cell apoptosis in CAD patients.
Since oxidative stress has been linked to NK cell apoptosis, we related the findings to
oxidative stress in vivo and evaluated the ex vivo susceptibility of NK cells to oxidized lipids.
METHODS AND RESULTS: The number of apoptotic NK cells in peripheral blood was …