Role of group 3 innate lymphoid cells in antibody production

G Magri, A Cerutti - Current opinion in immunology, 2015 - Elsevier
G Magri, A Cerutti
Current opinion in immunology, 2015Elsevier
Highlights•ILCs are helper lymphocytes of the innate immune system.•ILC3 shape the
development of lymphoid organs.•ILC3 regulate adaptive immunity, including the activation
of T and B lymphocytes.•ILC3 enhance T-dependent and T independent antibody responses
by B cells.•ILC3 promote systemic IgM and IgG production as well as mucosal IgA
production.Innate lymphoid cells (ILCs) constitute a heterogeneous family of effector
lymphocytes of the innate immune system that mediate lymphoid organogenesis, tissue …
Highlights
  • ILCs are helper lymphocytes of the innate immune system.
  • ILC3 shape the development of lymphoid organs.
  • ILC3 regulate adaptive immunity, including the activation of T and B lymphocytes.
  • ILC3 enhance T-dependent and T independent antibody responses by B cells.
  • ILC3 promote systemic IgM and IgG production as well as mucosal IgA production.
Innate lymphoid cells (ILCs) constitute a heterogeneous family of effector lymphocytes of the innate immune system that mediate lymphoid organogenesis, tissue repair, immunity and inflammation. The initial view that ILCs exert their protective functions solely during the innate phase of an immune response has been recently challenged by evidence indicating that ILCs shape adaptive immunity by establishing both contact-dependent and contact-independent interactions with multiple hematopoietic and non-hematopoietic cells, including B cells. Some of these interactions enhance antibody responses both systemically and at mucosal sites of entry.
Elsevier