[HTML][HTML] Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100
H Bonig, D Chudziak, G Priestley… - Experimental …, 2009 - Elsevier
OBJECTIVE: The CXCR4 antagonist AMD3100 mobilizes hematopoietic stem/progenitor
cells (HSPC) in several species. Few data are available on the biology of HSPC mobilized
with AMD3100 as single agent. To further study the kinetics and properties of AMD3100–
mobilized HSPC, and to explore the size of mobilizable pools of HSPC targeted by
AMD3100, we studied the effect of a continuous infusion scheme with saturating doses of
AMD3100 [AMDi]. MATERIALS AND METHODS: Using established procedures, we …
cells (HSPC) in several species. Few data are available on the biology of HSPC mobilized
with AMD3100 as single agent. To further study the kinetics and properties of AMD3100–
mobilized HSPC, and to explore the size of mobilizable pools of HSPC targeted by
AMD3100, we studied the effect of a continuous infusion scheme with saturating doses of
AMD3100 [AMDi]. MATERIALS AND METHODS: Using established procedures, we …